Where to start:

The sunniest spot in your yard is the best place to stake out your plot, because most vegetables need a minimum of 6 hours of sun daily. Because vegetables like lots of moisture, grow yours near a water source. Finally, vegetables always have the unwanted company of weeds, so monitor your plot weekly to pull up invaders as you watch your vegetables grow.
How your rows should run:

In temperate climates, make sure your vegetable rows run from east to west so that all the plants receive maximum sunshine. In hot, arid climates, run the rows from north to south so that each plant will shade its neighbour.
Make neat, straight rows

This is especially important if you use a tiller to cultivate between plantings, but it’s harder than it looks to do freehand! For planting heavy seeds, such as beans, put sticks in the ground at each end of a row and run a string between them to guide you as you plant. To plant dozens of lightweight seeds at once, cut a piece of string the same length as the row, wet it thoroughly, and sprinkle the seeds directly on it. The moisture will make seeds stick long enough to lay the string in a prepared furrow. Just cover the string with soil and you’re done!